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A retrospective cohort of 6,453 CHB patients who received HCC surveillance was constructed from the electronic clinical data warehouse.Covariates of AFP elevation were determined from 53,137 AFP measurements, and covariate-specific receiver operating characteristics regression analysis revealed that albumin levels and exposure to NA therapy were independent determinants of AFP performance.ABSTRACT: Although alpha-fetoprotein (AFP) is the most widely used biomarker in hepatocellular carcinoma (HCC) surveillance, disease activity may also increase AFP levels in chronic hepatitis B (CHB).Since nucleos(t)ide analog (NA) therapy may reduce not only HBV viral loads and transaminase levels but also the falsely elevated AFP levels in CHB, we tried to determine whether exposure to NA therapy influences AFP performance and whether selective application can optimize the performance of AFP testing in CHB during HCC surveillance.Classification accuracy is the ability of a marker or diagnostic test to discriminate between two groups of individuals, cases and controls, and is com- monly summarized by using the receiver operating characteristic (ROC) curve.We describe three ways of using covariate information.

Springer, Cham In medical studies, the receiver operating characteristic (ROC) curve is a tool of extensive use to analyze the discrimination capability of a diagnostic variable.

We provide theoretical arguments for the validity of the estimator and demonstrate its application to data.

We compare the statistical properties of the estimator with those of a previously proposed estimator of the covariate adjusted ROC curve.

These methods follow naturally when representing the ROC curve as a summary of the distribution of case marker observations, standardized with respect to the control distribution. Keywords: roccurve; comproc; rocreg; receiver operating characteristic analysis; ROC; covariates; sensitivity; specificity (search for similar items in Econ Papers) Date: 2009 References: View references in Econ Papers View complete reference list from Cit Ec Citations View citations in Econ Papers (1) Track citations by RSS feed Downloads: (external link)

article=st0155 (text/html) Related works: This item may be available elsewhere in Econ Papers: Search for items with the same title.

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